More than movement: the proprioceptive system as a new regulator of musculoskeletal biology

The proprioceptive system is essential for the control of coordinated movement and posture. Thus, traditionally, study proprioception has focused on its role in motor control. In this review, we present more recent findings other, non-traditional functions system. We focus involvement musculoskeletal development, function pathology, including regulation spinal alignment, bone fracture repair joint morphogenesis. hypothesis that plays a central biology, understanding underlying molecular mechanisms will promote both basic science medical innovations. As an example, discuss evidence indicating Piezo2, key mechanosensitive ion channel proprioception, regulates spine alignment development. presented show wide range developmental physiological processes dysfunction may contribute to etiology various pathologies.